PAC1R antagonist 1( —— )

Catalog No. M37140 CAS No. 2305204-24-2

PAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasms and immune-related disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

PAC1R antagonist 1
Note

Research use only, not for human use.
Brief Description

PAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasms and immune-related disorders.
Description

PAC1R antagonist 1 (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PACAP
Research Area

——
Indication

——

Chemical Information

CAS Number

2305204-24-2
Formula Weight

372.81
Molecular Formula

C17H17ClN6O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (89.40 mM; ultrasonic and warming and heat to 160°C )
SMILES

O=C(NCCC1=CN=CN1)C2CC(=O)N(C3=NNC=4C(Cl)=CC=CC34)C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Takasaki I, et, al. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2020 Jan 15;186:111902. ?

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